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Absence of GP130 cytokine receptor signaling causes

Drug discovery and development anchored in human genetic target validation. DEEP. A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical- Genetic Profiling in Staphylococcus aureus. Cell Chemistry and Biology 2011, 30 Jun 2020 Seven genetic mouse lines were used: global OSM (oncostatin M) knockout, monocyte-/macrophage-specific OSM deletion, cardiomyocyte- 28 Feb 2021 Mouse gp130 APC-conjugated Antibody R&D Systems catalog: Human gp130 PE-conjugated Antibody gene information - human gp130. The gene IL6ST encodes GP130, the common signal transducer of the IL-6 cytokine family consisting of 10 cytokines.

Gp130 gene

Exosomal gp130, which is highly enriched in cancer exosomes, triggers the secretion of IL-6 from BMDMs. Moreover, the exposure of BMDMs to cancer-derived exosomes triggers changes from a conventional toward a polarized phenotype often observed in tumor-associated macrophages. 2020-07-27 · We measured the activation of gp130 and of the pathway-related genes that identified through gene ontology and ingenuity pathway analysis in primary neonatal mouse cardiomyocytes by Western blot. We found that gp130 was activated in cardiomyocytes after 24 hours of OSM treatment.

Diseases associated with IL6ST include kaposi's sarcoma, and rheumatoid arthritis. GO annotations related to this gene include interleukin-6 receptor binding and protein homodimerization activity. An important paralog of this gene is OSMR.

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Target Information. The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor 23 Aug 2016 As driving gp130-mediated oncogenic mechanism, we detected a decreased expression of antioxidant genes, in particular glutathione La glucoproteína 130 (también conocida como gp130, IL6ST, IL6-beta o CD130) es una «Human gp130 transducer chain gene (IL6ST) is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11». gp130 Gene Expression in Rat Hepatocytes.

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gp130/IL6ST overexpression lysate was created in HEK293 Cells, CHO Cells and intended The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM).

Konjugation, Unconjugated. Reaktivitet, Human,Rat,Mouse. Värd, Rabbit. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis.
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We found that gp130 was activated in cardiomyocytes after 24 hours of OSM treatment. Simultaneously, STAT3 and Erk1/2 were also both activated. 2019-08-08 · Third, L-gp130 BM and manifest tumors are transplantable, allowing additional gene editing of FL and BM cells in vitro with subsequent syngeneic transplantation. Fourth, beyond the context of tumor pathogenesis, it allows targeting of gp130/JAK/STAT3 activation to specific cellular components or tissues that are involved in inflammation and immunity, e.g., in arthritis ( 8 ). gp130 gene and two SNPs in the LIFR gene were analyzed using real-time PCR. One significant difference and a tendency to difference were detected in the gp130 gene for women with unexplained infertility.

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Anti-GP130 Rabbit Polyclonal Antibody Alexa Fluor® 647

The intracellular domain has a consensus nucleotide-binding domain, but it has no protein kinase catalytic domain. Interleukin 6 signal transducer (Gp130, oncostatin M receptor) 2 dagar sedan · c, The authors report that a gp130 inhibitor molecule called bazedoxifene prevented gene expression that leads to damage in a zebrafish model of Crohn’s disease. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. Entrez Gene Summary for IL11RA Gene Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. Status. Unreviewed - Annotation score: Annotation score:1 out of 5.

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Chromosome 5: 55,935,095 -55,995,022 reverse strand. GRCh38:CM000667.2. About this gene.

The LIFR gene is regulated by alternate promoters, with a so called ‘general’ and Glycoprotein 130 (also known as gp130, IL6ST or CD130) is a transmembrane protein which is the founding member of the class of tall cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. Functional redundancy of the IL-6 cytokine family results from the use of the common receptor subunit gp130, 2 while the pleiotropic actions are associated with the coordinated and simultaneous activation of multiple signaling cascades which ultimately modulate gene expression and cellular responses. Gene target CD130 gp130 Receptor Oncostatin M-R OSM-R IL-6 Signal Transducer Alternative to gene target oncostatin M, OSM and IDBG-4002 and ENSG00000099985 and 5008, growth factor activity, Extracellular, Osm and IDBG-142284 and ENSMUSG00000058755 and 18413, BT.45038 and IDBG-636338 and ENSBTAG00000016163 and 319086 genes co-occuring with the biological term gp130 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. CNTF-CNTFR- gp130 -LIFR complex Gene Set Three SNPs in the gp130 gene and two SNPs in the LIFR gene were analyzed using real-time PCR. One significant difference and a tendency to difference were detected in the gp130 gene for women with unexplained infertility. There were no differences in the LIFR gene variations. 27 antibodies to GP130 and validated for use in 8 applications (Immunohistochemistry, Western Blot, Flow Cytometry, Immunoprecipitation, Immunocytochemistry, Immunofluorescence, ELISA, Neutralization) sIL-6ST/gp130/CD130 Human ELISA Kit from Invitrogen (96 Tests).