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CAN04 binds interleukin 1 receptor | January 11, 2021 Cantargia AB (publ) and Patheon Biologics B.V. (part of ThermoFischer Scientific) have signed an agreement regarding future production of the antibody CAN04 (nidanilimab). CAN04 is currently in phase IIa clinical development for non-small cell lung cancer and pancreatic cancer. Hereby, Cantargia secures additional production capacity for future clinical trials. The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. Preclinical data show that CAN04 increases the efficacy of chemotherapy. CAN04 is investigated in a phase I/IIa clinical trial, STOCKHOLM, April 7, 2020 /PRNewswire/ -- Cantargia AB today announced that the application for a US IND regarding the antibody CAN04 has been submitted to the US FDA. CAN04, an antibody targeting interleukin 1 receptor accessory protein (IL1RAP), is currently being investigated for treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer (PDAC) in phase IIa clinical development in 2019-01-28 2019-06-03 The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1α and IL-1β signaling.

Can04 antibody

Preclinical data show that CAN04 can Cantargia develops antibody-based pharmaceuticals against the interleukin 1 receptor accessory protein (IL1RAP). The antibody CAN04 binds IL1RAP with high affinity and functions through both ADCC The antibody CAN04 binds IL1RAP with high affinity and functions through both Antibody-Dependent Cellular Cytotoxicity (ADCC) and blockade of IL-1 signaling. A new phase Ib clinical trial investigates CAN04 in combination with pembrolizumab which targets PD-1 (https: The antibody CAN04 binds IL1RAP with high affinity and functions through both blockade of IL-1 signaling and Antibody-Dependent Cellular Cytotoxicity (ADCC). Preclinical data show that CAN04 can increase the efficacy of chemotherapy.

The CAN04 strategy is to attack the IL1RAP target molecule using an effective antibody-based cancer treatment.

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Cantargia AB (”Cantargia”) today announces that the United States Patent and Trademark Office (“USPTO”) has granted the company’s patent application directed to Cantargia AB today announced the submission of a clinical trial application investigating antibody CAN04 in combination with FOLFIRINOX for first line treatment of metastatic pancreatic cancer . The | … • Anti-Drug Antibodies (ADA) against CAN04. Preliminary signs of efficacy • Overall Response Rate (ORR) using irRC (Part I and Part II Arms A, B, and E), iRECIST (Part II, Arms C and D) and RECIST 1.1 (both Part I and II); with irRC (before protocol version 7.0) or iRECIST (from protocol version 7.0 onwards) to be the decision-making criteria.

Engineered into new species and isotypes to improve your experiments. Bulk anti-CTLA-4 In Vivo Antibody - Low Endotoxin (9D9) Bio X Cell: ICH1096 is up to 26% cheaper for academia & non-profits and up to 58% cheaper for in. Apr 16, 2019 In an antibody cocktail, different antibodies are mixed together during manufacturing.
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Antibody-Dependent Cellular Cytotoxicity (ADCC) och Cantargia has formally applied to start a phase I/IIa clinical trial with its proprietary antibody CAN04, directed towards the molecular target IL1RAP Cantargia AB: Cantargia submits application to start new clinical trial investigating antibody CAN04 and FOLFIRINOX in pancreatic can. 2021-03-09 00:30:00. CAN04, the Company's patented antibody, has a dual mechanism of action. It fights cancer by activating the immune system and by blocking Cantargia's Phase IIa CANFOUR trial investigates CAN04 in a combination by an established mechanism ADCC (antibody-dependent cellular cytotoxicity). Antikroppen CAN04 binder IL1RAP med hög affinititet och fungerar både genom blockad av IL-1-signalering samt s k Antibody-Dependent Cellular Cytotoxicity Antikroppen CAN04 binder IL1RAP med hög affinitet och fungerar både genom s.k.

The lead candidate CAN04 is for treatment of solid tumors and hematoligacal cancers, Feb 10, 2021 The antibody CAN04 binds IL1RAP with high affinity and functions through both blockade of IL-1 signaling and Antibody-Dependent Cellular Rabbit mAbs were isolated using selected lymphocyte antibody method (SLAM) CAN-04-0240 pmid:http://www.ncbi.nlm.nih.gov/pubmed/15289306.
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Pancreatic cancer. Immuno-. Oncology. Available.

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Jun 16, 2020 for pre-clinical evaluation of CAN04 for lung and pancreatic cancer of a a novel antibody, CAN04, under development for this indication. investigating antibody CAN04 and FOLFIRINOX in pancreatic can. 2021-03-10 08:30:00 Other information disclosed according to the rules of the Exchange Oct 6, 2017 In this trial the antibody CAN04, directed towards the molecular target IL1RAP, will be investigated in patients with cancer. The CAN04 antibody May 9, 2018 lead candidate is the antibody CAN04, which has a dual mechanism of antibody attaches to the IL1RAP receptor molecule and blocks it from Mar 5, 2015 wherein the antibody or antigen-binding fragment is capable of inhibiting the binding of reference antibody 'CAN04' to human IL1RAP. Mar 1, 2021 The main project, the antibody CAN04, is being studied clinically as combination therapy with chemotherapy or immune therapy with a primary Aug 23, 2019 The investigational antibody CAN04 binds IL1RAP with high affinity and functions through both ADCC and blockade of interleukin 1 signaling.

CAN04 is currently produced in a Chinese Hamster Ovary (CHO) cell line provided by BioWa which has been engineered using POTELLIGENT® Technology. FIGS. 4A-C. Ability of exemplary antibody CAN04 to block (4A) IL-1β (4B) IL-1α, and (4C) IL-33 signalling.